CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis
نویسندگان
چکیده
Relationships between concentrations of cerebrospinal fluid (CSF) kynurenic acid (KYNA) and suicidal behavior were evaluated in 59 patients with psychosis after 22 years of follow-up. Three patients died from suicide and nine patients had a history of attempted suicide. Patients with attempted suicide had significantly lower concentrations of CSF KYNA.
منابع مشابه
Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
BACKGROUND The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. METHODS Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. RESU...
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BACKGROUND Patients with schizophrenia show increased brain and cerebrospinal fluid (CSF) concentrations of the endogenous N-methyl-D-aspartate receptor antagonist kynurenic acid (KYNA). This compound is an end-metabolite of the kynurenine pathway, and its formation indirectly depends on the activity of kynurenine 3-monooxygenase (KMO), the enzyme converting kynurenine to 3-hydroxykynurenine. ...
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BACKGROUND The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and α7* nicotinic receptors. METHODS The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA an...
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OBJECTIVE To study the change in risk of suicide among patients with schizophrenia and related disorders. DESIGN Nested case-control design with linked data. SETTING 4 longitudinal Danish registers. PARTICIPANTS 18,744 people aged up to 75 years who committed suicide in 1981-97 individually matched with 20 controls. RESULTS Over the time studied the reduction in suicide rate among patie...
متن کاملPii: S0304-3940(01)02242-x
Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl daspartate-receptor. Mounting evidence indicate that the compound is significantly involved in basal neurophysiological processes in the brain. In the present investigation, cerebrospinal fluid (CSF) level of kynurenic acid was analyzed in 28 male schizophrenic patients and 17 mal...
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ورودعنوان ژورنال:
- Psychiatry Research
دوره 205 شماره
صفحات -
تاریخ انتشار 2013